The Terriers were 18th in the table when coronavirus saw the 2019/20 campaign suspended, but sit just three points above the drop zone having won just 11 of their 37 league outings this term.
Wigan are only one point behind in 20th, so Danny Cowley and his men know that securing a positive outcome from their first game back is hugely important.
With plenty riding on the outcome of the clash with the Latics, here's a look at the Town players who will be in contention for selection next week.
One notable absentee will be experienced centre-half Tommy Elphick, who has begun light training following a knee ligament injury suffered in November, but is not expected to feature again until 2020/21.
Pictures: Getty Images