Match Centre: Bradford City, Hull City, Leeds United, Sheffield Wednesday
Bradford City host Preston North End looking to claim a second scalp in the competition, while Hull City will hope to avoid a giant-killing when they visit Brentford.
Sheffield Wednesday of League One travel to Championship side Scunthorpe hoping to knock out a team from a higher division while Leeds United entertain Leicester City in the all-Championship clash.
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Hide AdWelcome to the Yorkshire Post's exciting match-day service, called Match Centre. Here you will find minute-by-minute updates, stats and team formations. Plus reports from every game in England, from the Premier League down to the Blue Square Premier.
Simply select your game from the pull down menu, then click on the 'i' information button on the right of the fixture and it will give you access to everything you need to know about your team.
So if you can't make it to a game, head for the Match Centre and we will give you the best seat in the house. Click the link below.
For the latest team news, score and commentary from your team check out our new Match Centre
For full match reports read Wednesday's Yorkshire Post.