Wane will announce his squad at a press conference in Manchester on Friday morning and, as ever, his selections will be hotly debated.
England are set to take on Fiji in a warm-up match at Salford on October 7, although Wane is unlikely to select any of the Super League Grand Finalists from St Helens or Leeds Rhinos.
Wane’s men face a strong Samoa side at St James’ Park, Newcastle, on October 15 before dates with France and Greece in their other group fixtures.
If England lose their opening game, they would be likely to face the might of Tonga in the quarter-finals.
Wane has suffered a number of setbacks with Alex Walmsley, Liam Farrell and Harry Newman among those ruled out by injury.
Here, The Yorkshire Post has a go at predicting Wane’s squad for the tournament.